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Neuronal calcium sensor-1 (NCS-1) also known as frequenin homolog (Drosophila) (freq) is a protein that is encoded by the ''FREQ'' gene in humans. NCS-1 is a member of the neuronal calcium sensor family, a class of EF hand containing calcium-myristoyl-switch proteins. == Function == NCS-1 regulates synaptic transmission, helps control the dynamics of nerve terminal growth, is critical for some forms of learning and memory in ''C. elegans'' and mammals, regulates corticohippocampal plasticity; and enhancing levels of NCS-1 in the mouse dentate gyrus increases spontaneous exploration of safe environments,〔potentially linking NCS-1 to curiosity. NCS-1 is a calcium sensor, not a calcium buffer (chelator); thus it is a high-affinity, low-capacity, calcium-binding protein. Frq can substitute for calmodulin in some situations. It is thought to be associated with neuronal secretory vesicles and regulate neurosecretion. # It is the Ca2+-sensing subunit of the yeast phosphatidylinositol (PtdIns)-4-OH kinase, PIK1 # It binds to many proteins, some in calcium dependent and some in calcium independent ways, and switches many of the targets "on" (some off). ## Calcineurin (protein phosphatase 2B) ## GRK2 (G-protein-coupled receptor kinase 2) ## D2 dopamine receptor ## IL1RAPL1 (interleukin-1 receptor accessory protein-like 1 protein) ## PI4KIIIβ (type III phosphatidylinositol 4-kinase β) ## IP3 receptor (this activity is inhibited by lithium - a drug used for the treatment of bipolar disorder) ## 3',5'-cyclic nucleotide phosphodiesterases ## ARF1 (ADP Ribosylation factor 1) ## A type (Kv4.3; Shal-related subfamily, member 3) voltage-gated potassium channels ## Nitric oxide synthase ## TRPC5 channel ## Ric8a # Frq modulates Ca2+ entry through a functional interaction with the α1 voltage-gated Ca2+-channel subunit.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Neuronal calcium sensor-1」の詳細全文を読む スポンサード リンク
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