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NDEL1
Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the ''NDEL1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81565 )〕 This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.〔 == Interactions ==
NDEL1 has been shown to interact with Cyclin-dependent kinase 5,〔 YWHAE, PAFAH1B1〔〔 and DISC1.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「NDEL1」の詳細全文を読む
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