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・ NDUFA2
・ NDUFA3
・ NDUFA4
・ NDUFA4L2
・ NDUFA5
・ NDUFA6
・ NDUFA7
・ NDUFA8
・ NDUFA9
・ NDUFAB1
・ NDUFAF1
・ NDUFB1
・ NDUFB10
・ NDUFB11
・ NDUFB2
NDUFB3
・ NDUFB4
・ NDUFB5
・ NDUFB6
・ NDUFB7
・ NDUFB8
・ NDUFB9
・ NDUFC1
・ NDUFC2
・ NDUFS1
・ NDUFS2
・ NDUFS3
・ NDUFS4
・ NDUFS5
・ NDUFS6


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NDUFB3 : ウィキペディア英語版
NDUFB3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa is a protein that in humans is encoded by the NDUFB3 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain. Mutations in this gene contribute to mitochondrial complex I deficiency.
== Structure ==

The NDUFB3 gene, located on the q arm of chromosome 2 in position 31.3, is 14,012 base pairs long. The NDUFB3 protein weighs 12 kDa and is composed of 104 amino acids.〔(【引用サイトリンク】 work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) )〕 NDUFB3 is a subunit of the enzyme NADH dehydrogenase (ubiquinone), the largest of the respiratory complexes. The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox centers and the NADH binding site.〔 NDUFB3 is one of about 31 hydrophobic subunits that form the transmembrane region of Complex I. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of Complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and that the hydrophobic domain acts as an anchor for the NADH dehydrogenase (ubiquinone) complex at the inner mitochondrial membrane.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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