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NEDD1
Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene 〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=121441 )〕 and encodes the protein NEDD1. NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「NEDD1」の詳細全文を読む
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