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NIPBL
Nipped-B-like protein (NIPBL), also known as delangin or SCC2 homolog is a protein that in humans is encoded by the ''NIPBL'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25836 )〕 == Function ==
This gene encodes the homolog of the ''Drosophila melanogaster'' Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat domain. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「NIPBL」の詳細全文を読む
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