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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク NRX-1074 ： ウィキペディア英語版 NRX-1074 NRX-1074 (threonyl-prolyl-2R-(2-benzyl)-prolyl-threonine amide) is an orally-active experimental pharmaceutical and selective partial agonist of the glycine site of the NMDA receptor which is under investigation as a novel antidepressant drug. The drug was developed by Naurex for the treatment of major depressive disorder (MDD).〔(【引用サイトリンク】 author = PR Newswire )〕〔(【引用サイトリンク】 author = PR Newswire )〕 Its mechanism of action and effects are similar to those of rapastinel (GLYX-13), which is under development as an adjunctive therapy for treatment-resistant depression also by Naurex, however NRX-1074 is hundredfold more potent by weight and, unlike GLYX-13, orally-active.〔 NRX-1074 has shown rapid antidepressant effects in preclinical models of depression.〔 In addition, similarly to GLYX-13, it is well-tolerated and lacks the schizophrenia-like psychotomimetic effects of other NMDA receptor antagonists such as ketamine.〔 As of 2015, an intravenous formulation of NRX-1074 is in a phase II clinical trial for MDD.〔 Concurrently, an oral formulation is in phase I trials for MDD. ==See also== * Rapastinel * AV-101 * Nebostinel * Esketamine * CERC-301 * ALKS-5461 * NSI-189 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「NRX-1074」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.