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NS-2664
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NS-2664 : ウィキペディア英語版
NS-2664

NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.〔Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? ''Journal of Pharmacology and Experimental Therapeutics''. 2006 Mar;316(3):1378-85. PMID 16352707〕
== References ==




抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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