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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク NXY-059 ： ウィキペディア英語版 Disufenton sodium Disufenton sodium (NXY-059, Cerovive) is the disulfonyl derivative of the neuroprotective spin trap phenylbutylnitrone or "PBN". It was under development at the drug company AstraZeneca. A 2005 phase-3 clinical trial called "SAINT-1" reported some efficacy in the acute treatment of ischemia injury due to stroke. However, a 2006 attempt to repeat this trial indicated no significant activity. After ruling out other causes, the authors tentatively attributed the positive results in the first trial to "chance".〔 AstraZeneca then terminated the development programme.〔(Renovis: Press Release )〕 PBN and its derivatives hydrolyze and oxidize ''in vitro'' to form respectively MNP-OH ( AKA, NtBHA ) and its parent spin-trap MNP. ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Disufenton sodium」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.