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Nadolol
Nadolol (Corgard) is a non-selective beta blocker used in the treatment of high blood pressure and chest pain. Additionally, it is often prescribed in the treatment of atrial fibrillation, migraine headaches, and complications of cirrhosis.
==Medical uses==
Nadolol is used to treat hypertension and for long-term treatment of angina pectoris and is approved by the FDA for these purposes.〔Nadolol entry in AccessMedicine. McGraw-Hill Global Education Holdings, LLC. Accessed November 8, 2014〕
It is regularly used off-label〔 for control of heart rate in people with atrial fibrillation,〔January CT, et al 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation. 2014 Apr 10. PMID 24682347〕 prevention of migraine headaches;〔Silberstein SD et al. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012 Apr 24;78(17):1337-45. PMID 22529202 PMC 3335452〕 prevention of bleeding veins in people with portal hypertension caused by cirrhosis;〔Giannelli V et al. Beta-blockers in liver cirrhosis. Ann Gastroenterol. 2014;27(1):20-26. PMID 24714633 PMC 3959530〕 and to treat people with high levels of thyroid hormone.〔Bahn RS et al, “Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists,” Thyroid, 2011, 21(6):593-646. PMID 21510801〕
Nadolol is one of the preferred beta-blockers in the management of patients with LQTS for shortening of the QT interval and prevention of ventricular arrhythmia. It is more efficacious than metoprolol in the prevention of breakthrough cardiac events while on therapy and is equivalent to propranolol. Nadolol has the advantage of once daily dosing and thus improved patient compliance. For patients with decreased renal function, nadolol may be dosed less often.〔http://reference.medscape.com/drug/corgard-nadolol-342361〕 It has also been found to be useful (off-label) for several neurological disorders such as the prevention of migraine attacks,〔http://patient.info/medicine/nadolol-a-beta-blocker-corgard〕 attention deficit/hyperactivity disorder(ADHD)〔https://books.google.com/books?id=EkyTTvjNRZAC&pg=PA669&lpg=PA669&dq=Nadolol+for+ADHD&source=bl&ots=AHBVTAhCwv&sig=w0nW8Plyub3GN87J7itGz1fB11Y&hl=en&sa=X&ei=UAjRVMWkJoatyQSDzoDQCA&ved=0CFEQ6AEwBTgK#v=onepage&q=Nadolol%20for%20ADHD&f=false〕〔http://psychcentral.com/disorders/sx1t.htm〕〔http://www.doctorshangout.com/profiles/blogs/nadolol-nonselective-long-acting-beta-blocker〕 and its use has been explored as a treatment for essential tremor〔Zesiewicz TA et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology. 2011 Nov 8;77(19):1752-5. PMID 22013182 PMC 3208950〕 and Parkinson's disease〔U.S. National Library of Medicine (Nadolol entry in Medline Plus )〕 but neither is well established.〔http://onlinelibrary.wiley.com/doi/10.1002/ana.410160412/abstract〕〔http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682666.html〕〔http://www.drugs.com/dosage/nadolol.html〕
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