翻訳と辞書 Words near each other ・ Naloxegol ・ Naloxol ・ Naloxonazine ・ Naloxone ・ NALP ・ NALP3 ・ Nalpathaneeswaram Sree Mahadeva Temple ・ Nalpaumia ・ Nalpha-benzyloxycarbonylleucine hydrolase ・ Nalpur ・ NALS ・ Nals ・ Nalsar University of Law ・ Nalsvi ・ NALT ・ Naltalimide ・ Naltar ・ Naltar lakes ・ Naltar Pass ・ Naltar Peak ・ Naltar Valley ・ Naltar Wildlife Sanctuary ・ Naltaş, Saimbeyli ・ Naltona ・ Naltor ・ Naltrexone ・ Naltriben ・ Naltrindole ・ Nalu ・ NALU at Fulham Correctional Centre Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Naltalimide ： ウィキペディア英語版 Naltalimide Naltalimide (INN) (code name TRK-130, formerly TAK 363) is a novel, centrally-acting opioid drug which is under development by Takeda and Toray for the treatment of overactive bladder/urinary incontinence.〔http://business.highbeam.com/436989/article-1G1-131689504/trk-130-takeda-toray-licensing-agreement〕 It acts as a potent and selective partial agonist of the μ-opioid receptor (Ki = 0.268 nM, EC50 = 2.39 nM, Emax = 66.1%) over the δ-opioid (Ki = 121 nM, EC50 = 26.1 nM, Emax = 71.0%) and κ-opioid receptors (Ki = 8.97 nM, EC50 = 9.51 nM, Emax = 62.6%).〔 Notably, naltalimide somehow appears to lack certain undesirable side effects such as constipation seen with other μ-opioid receptor agonists such as morphine.〔 It enhances bladder storage via suppression of the afferent limb of the micturition reflex pathway.〔 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Naltalimide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.