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Naltriben
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.〔Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. ''Journal of Pharmacology and Experimental Therapeutics''. 1991 May;257(2):676-80. PMID 1851833〕 It also acts as a κ-opioid agonist at high doses.〔Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. ''Life Sciences''. 1994;55(4):PL79-84. PMID 8028443〕 ==References==
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