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Necitumumab
Necitumumab (proposed INN) is a recombinant human IgG1 monoclonal antibody used as an antineoplastic. It binds to the epidermal growth factor receptor (EGFR).〔(International Nonproprietary Names for Pharmaceutical Substances (INN, prepublication copy) ), ''World Health Organization''.〕 The US FDA approved necitumumab under the brand name Portrazza for use with gemcitabine and cisplatin in previously untreated metastatic squamous non-small-cell lung carcinoma (NSCLC).〔http://www.medscape.com/viewarticle/854952?nlid=91969_3663&src=wnl_edit_newsal&uac=78316PX&impID=899999&faf=1〕〔http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm474278.htm〕〔http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125547s000lbl.pdf〕 It was counterproductive in non-squamous non-small-cell lung carcinoma.〔〔http://www.medscape.com/viewarticle/840768〕 ==References== 〔
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