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Nematode.net
Nematode.net (http://nematode.net)〔Martin J, Abubucker S, Heizer E, Taylor CM, Mitreva M. (2012) (Nematode.net update 2011: addition of data sets and tools featuring next-generation sequencing data. ) "Nucleic Acids Research." 40 (Database issue): D720-D728.〕〔Martin J, Abubucker S, Wylie T, Yin Y, Wang Z, Mitreva M. (2009) (Nematode.net update 2008: improvements enabling more efficient data mining and comparative nematode genomics. ) ''Nucleic Acids Research.'' 37 (suppl 1): D571-D578.〕 is a publicly available resource dedicated to the study of parasitic nematodes. It stemmed from an Expressed Sequence Tag (EST) project that began at The Genome Institute at Washington University in St. Louis, Missouri. The site was launched in 2000 to accompany the project “A Genomic Approach to Parasites from the Phylum Nematoda,”〔NIH Project Information on ("'A Genomic Approach to Parasites from the Phylum Nematoda’" )〕 funded by the National Institute of Allergy and Infectious Diseases (NIAID). It was created to provide access to the data from this project and as a broader resource for the scientific community studying parasitic nematodes.〔Wylie T, Martin J, Dante M, Mitreva M, Clifton SC, Chinwalla A, Waterston RH, Wilson RK, McCarter JP. (2004) (Nematode.net: a tool for navigating sequences from parasitic and free-living nematodes ) ''Nucleic Acids Research.'' 32 (suppl 1): D423-D426.〕
==History==
The first model nematode to be sequenced was ''Caenorhabditis elegans''. It was also the first fully sequenced genome of a multicellular organism to be completed.〔''C. elegans'' Sequencing Consortium. (1998) (Genome sequence of the nematode C. elegans: a platform for investigating biology. ) ''Science.'' Dec 11;282(5396): 2012-8.〕 Nematode.net built on these efforts to make available the gene sequences from medically and economically relevant parasitic nematodes.〔 Human parasitic nematodes, or roundworms, have wide-ranging global health implications, producing a disease burden that exceeds malaria and tuberculosis.〔Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. (2008) (Helminth infections: the great neglected tropical diseases. )'' Journal of Clinical Investigation.'' Apr;118(4):1311-21.〕 Plant parasitic nematodes cause over $100 billion in annual crop damage worldwide.〔Jasmer DP, Groverse A, Smant, G. (2003) (Parasitic nematode interactions with mammals and plants. ) ''Annu. Rev. Phytopathol.'' 41, 245–270.〕
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