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・ Nespelem (art)
・ Nespelem Community, Washington
・ Nespelem River
・ Nespelem tribe
・ Nespelem, Washington
・ Nespeš
・ Nesphostylis
・ Nespithe
・ Nesploy
・ Nespolino
・ Nespolo
・ Nespos
・ NESPOT
・ Nespouls
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Nesprin
・ Nespáľme to krásne v nás
・ Nesque
・ Nesquehoning
・ Nesquehoning Creek
・ Nesquehoning High School
・ Nesquehoning Mountain
・ Nesquehoning Valley Railroad
・ Nesquehoning, Pennsylvania
・ Nesquik
・ Nesquik (cereal)
・ Nesquik (disambiguation)
・ Nesquik (mix)
・ Nesr
・ Nesreen Ghaddar


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Nesprin : ウィキペディア英語版
Nesprin
The Nesprins (nuclear envelope spectrin repeat proteins〔http://jcs.biologists.org/cgi/content/abstract/114/24/4485〕) are a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments. They contain a C-terminal KASH transmembrane domain and are part of the LINC complex (Linker of Nucleoskeleton and Cytoskeleton) which is a protein network that associates the nuclear envelope (the membrane surrounding the nucleus) to the cytoskeleton, outside the nucleus, and the nuclear lamina, inside the nucleus. Nesprin-1 and -2 bind to the actin filaments. Nesprin-3 binds to plectin, which is bound to the intermediate filaments, while nesprin-4 interacts with kinesin-1.
Nesprin mediated connections to cytoskeleton provides mechanosensory functions in cells as the dislocation of Nesprin from nuclear envelope interferes with cells ability to sense and respond to mechanical challenges.
==See also==

* SYNE1
* SYNE2

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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