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Nesprin The Nesprins (nuclear envelope spectrin repeat proteins〔http://jcs.biologists.org/cgi/content/abstract/114/24/4485〕) are a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments. They contain a C-terminal KASH transmembrane domain and are part of the LINC complex (Linker of Nucleoskeleton and Cytoskeleton) which is a protein network that associates the nuclear envelope (the membrane surrounding the nucleus) to the cytoskeleton, outside the nucleus, and the nuclear lamina, inside the nucleus. Nesprin-1 and -2 bind to the actin filaments. Nesprin-3 binds to plectin, which is bound to the intermediate filaments, while nesprin-4 interacts with kinesin-1. Nesprin mediated connections to cytoskeleton provides mechanosensory functions in cells as the dislocation of Nesprin from nuclear envelope interferes with cells ability to sense and respond to mechanical challenges. ==See also==
* SYNE1 * SYNE2
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Nesprin」の詳細全文を読む
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