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Nestorone : ウィキペディア英語版
Nestorone

Nestorone (or nesteron), also known as elcometrine and ST-1435, is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive in several South American countries.
Nestorone is only weakly active orally, and is instead given as a subcutaneous implant. It is more than 100-fold times as potent when delivered subcutaneously relative to orally.〔
Nestorone acts primarily as a high-affinity agonist of the progesterone receptor. It lacks significant affinity for the androgen receptor, and accordingly, does not produce any androgenic or anabolic effects. It does not bind to the estrogen receptor either. Nestorone does however have some affinity for the glucocorticoid receptor, where it appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses.〔 It does not bind to the mineralocorticoid receptor.
Nestorone does not bind to sex hormone-binding globulin, and is instead bound to serum albumin.〔
==See also==

* Levonorgestrel
* Etonogestrel
* Nomegestrol acetate

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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