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Neuvenge, Lapuleucel-T (APC 8024), is a therapeutic cancer vaccine (TCV) in development (clinical trial) by Dendreon (DNDN). It uses the "immunotherapy platform approach" first successfully demonstrated on the U.S. Food and Drug Administration (FDA)-approved TCV Provenge. It was first tested on breast cancer patients with tumors expressing HER2/neu, and is now scheduled to be tested on bladder cancer patients.〔(Lapuleucel-T | Singularity Hub )〕 ==History== The concept of immunotherapy for cancer has been known for hundreds of years and was used by Dr William Coley et al. in the 1800s.〔http://www.oncbiz.com/documents/OBR_JAN10_CV.pdf〕 Coley's Toxins are still available outside of the US. The idea of harnessing the antigen presenting cells (APC)'s to recognize cancer and target tumor cells for apoptosis (cell death) by the CD8 (cytotoxic cells) is a common approach to cancer vacine researchers. This 1997 example article describes targeting EGFR and other cell products and attaching their antigens to the CD64 receptor cells also using GM-CSF to grow more cells. The NIH calls this topic "Biological response modifiers (BRMs) occur naturally in the body and can be produced in the laboratory. BRMs alter the interaction between the body's immune defenses and cancer cells to boost, direct, or restore the body's ability to fight the disease." 〔(Biological Therapies for Cancer: Q & A - National Cancer Institute )〕 Immunocompromising diseases have caused many deaths in human history. An ongoing example is Karposi's sarcoma (KS) caused by the Human herpesvirus 8 virus normally controlled by the body's immune system. KS is normally a rare disease but AIDS has made it all to commonplace. AIDS patients, whose immune system has been compromised, fall victim to serious opportunistic infections such as (TB) and KS. The movie "Philadelphia (film)" gives a dramatic representation of AIDS and KS. A good method of preventing some cancers is to stop the viruses that lead to them. This is known as prophylatic treatment. The current cancer prophylactic vaccines are for Hepatitis B virus (HBV), HPV (cervical cancer, vaginal, vulvar cancer, penile, anal cancer) and HPV-positive oropharyngeal cancer are all defenses utilizing immunotherapy against viruses that lead to cancer. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Neuvenge」の詳細全文を読む スポンサード リンク
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