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Nigericin : ウィキペディア英語版
Nigericin

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Nigericin is an antibiotic derived from ''Streptomyces hygroscopicus''. Its isolation was described in the 1950s, and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464.
Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+.
In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the ] functions in Eukaryotic cells.
== References ==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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