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Nitrovasodilator
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Nitrovasodilator : ウィキペディア英語版
Nitrovasodilator

A nitrovasodilator is a pharmaceutical agent that causes vasodilation (widening of blood vessels) by donation of nitric oxide (NO), and is mostly used for the treatment and prevention of angina pectoris.
This group of drugs includes nitrates (esters of nitric acid), which are reduced to NO in the body. Examples are:
* glyceryl trinitrate (nitroglycerine)
* isosorbide mononitrate and dinitrate
* itramin
* pentaerithrityl tetranitrate
* propatylnitrate
* tenitramine
* trolnitrate
* and nicorandil (which additionally acts as a potassium channel opener)
Nitrovasodilators which aren't nitrates include molsidomine and its active metabolite linsidomine, as well as sodium nitroprusside. These substances do not need to be reduced to donate NO.〔
== Medical uses ==
The nitrates are used for the treatment and prevention of angina and acute myocardial infarction, while molsidomine acts too slowly to be useful for the treatment of acute angina.〔 For quick action in the treatment of angina, glyceryl trinitrate is used in form of a sublingual spray (nitro spray) or as soft capsules to be crunched.
Nitroprusside is used intravenously for the treatment of hypertensive crises, heart failure, and lowering of blood pressure during surgery.〔Sodium nitroprusside: .〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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