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Norbuprenorphine
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Norbuprenorphine : ウィキペディア英語版
Norbuprenorphine

Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist, and a κ-opioid receptor partial agonist.〔 In rats, unlike buprenorphine, norbuprenorphine produces marked respiratory depression but with very little antinociceptive effect. In explanation of these properties, norbuprenorphine has been found to be a high affinity P-glycoprotein substrate, and in accordance, shows very limited blood-brain-barrier penetration.〔
==See also==

* Norbuprenorphine-3-glucuronide
* Buprenorphine-3-glucuronide
* Loperamide

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Norbuprenorphine」の詳細全文を読む



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