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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Norbuprenorphine-3-glucuronide ： ウィキペディア英語版 Norbuprenorphine-3-glucuronide Norbuprenorphine-3-glucuronide (N3G) is a major active metabolite of the opioid modulator buprenorphine. It has affinity for the κ-opioid receptor (Ki = 300 nM) and the nociceptin receptor (Ki = 18 μM), but not for the μ- or δ-opioid receptors.〔 Whether N3G acts as an agonist or antagonist of the former two sites has yet to be determined. In animals, N3G has been found to produce sedation, decreased locomotion, and a small amount of antinociception, properties which are consistent with the effects of κ-opioid receptor agonists.〔 In addition, N3G has been found to reduce tidal volume but not respiratory rate.〔 Unlike norbuprenorphine, but similarly to buprenorphine and buprenorphine-3-glucuronide, N3G is not a substrate for P-glycoprotein.〔 However, due to its highly hydrophilic nature, N3G nonetheless passes the blood-brain-barrier in only very small amounts.〔 ==See also== * Morphine-3-glucuronide 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Norbuprenorphine-3-glucuronide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.