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Noribogaine
Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the psychedelic drug ibogaine. It is thought to be involved in the anti-addictive effects of ibogaine-containing plant extracts. A recent study evaluated its effects on healthy volunteers at doses of 3–60 mg, finding no tolerability issues. A slow half-life of 28–49 hours was seen with large volume of distribution. == Pharmacology == Noribogaine inhibits serotonin uptake more than ibogaine but does not affect dopamine. It has greater affinity for serotonin transporters and less at sigma-2 receptors. In binding studies noribogaine has a greater affinity at each opioid receptor than ibogaine. Ki-values in μM
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