翻訳と辞書 Words near each other ・ Normie Osborn ・ Normie Rowe ・ Normie Roy ・ Normie Smith ・ Normier ・ Normington ・ NORML New Zealand ・ NORML UK ・ NORMOB ・ Normoblast ・ Normocapnia ・ Normochromic anemia ・ Normocytic anemia ・ Normolipoproteinemic xanthomatosis ・ Normophosphatemic familial tumoral calcinosis ・ Normorphine ・ Normoxic ・ Norms of Liberty ・ Norms Restaurants ・ Normski ・ Normunds Miezis ・ Normunds Pūpols ・ Normunds Sietiņš ・ Normunds Sējējs ・ Normétal ・ Norn ・ NORN (clothing brand) ・ Norn iron works ・ Norn language ・ Norn Stones Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Normorphine ： ウィキペディア英語版 Normorphine Normorphine is an opiate analogue, the N-demethylated derivative of morphine, that was first described in the 1950s〔Journal of the American Chemistry Society 75,4963 (1953)〕 when a large group of N-substituted morphine analogues were characterized for activity. Normorphine has relatively little opioid activity in its own right,〔Fraser HF, Wikler A, Van Horn GD, Eisenman AJ, Isbell H. Human pharmacology and addiction liability of normorphine. ''Journal of Pharmacology and Experimental Therapeutics''. 1958 Mar;122(3):359-69. PMID 13539761〕〔Lasagna L, De Kornfeld TJ. Analgesic potency of normorphine in patients with postoperative pain. ''Journal of Pharmacology and Experimental Therapeutics''. 1958 Nov;124(3):260-3. PMID 13588540〕 but is a useful intermediate which can be used to produce both opioid antagonists such as nalorphine, and also potent opioid agonists such as N-phenethylnormorphine.〔Daniel Lednicer. Central Analgetics. (1982), p146. ISBN 0-471-08314-3 〕 It is also produced as a major metabolite of morphine,〔Yeh SY. Urinary excretion of morphine and its metabolites in morphine-dependent subjects. ''Journal of Pharmacology and Experimental Therapeutics''. 1975 Jan;192(1):201-10. PMID 235634〕 with its formation from morphine catalysed by the liver enzymes CYP3A4 and CYP2C8.〔Projean D, Morin PE, Tu TM, Ducharme J. Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. ''Xenobiotica''. 2003 Aug;33(8):841-54. PMID 12936704〕 Normorphine is a controlled substance listed under the Single Convention On Narcotic Drugs 1961 and the laws in various states implementing it; for example, in the United States it is a Schedule I Narcotic controlled substance, with an ACSCN of 9313 and an annual aggregate manufacturing quota of 18 grammes in 2013, unchanged from the prior year. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Normorphine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.