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Nortilidine
Nortilidine〔US Patent 3792080 - (Process for Substituted Cyclohexenes its Products )〕 is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine〔J Clin Pharmacol. 2002 Nov ;42 (11):1257-61 - Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine〕 but virtually all of the opioid activity resides in the (1S,2R) isomer.〔Opiates: George R. Lenz page 439, Table 9-30 (78)〕 The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. ==See also==
* O-Desmethyltramadol
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Nortilidine」の詳細全文を読む
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