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Nuocyte
The nuocyte is a cell of the innate immune system that plays an important role in type 2 immune responses that are induced in response to helminth worm infection or in conditions such as asthma and atopic disease. Nuocytes are amongst the first cells activated in type 2 immune responses and are thought to play important roles in activating and recruiting other cells types through their production of type 2 cytokines interleukin 4, 5 and 13.〔 Nuocytes have been observed to proliferate in the presence of IL-7 ''in vitro''. Nuocytes contribute to the expulsion of helminth worms 〔 and to the pathology of colitis and allergic airways disease.
The nuocyte was identified at the same time as several other immune cells that play similar roles in type 2 immunity. These include Natural Helper Cells (NHCs), Innate Helper 2 (Ih2) cells and Multi-Potent Progenitor (MPP) type 2 cells. The exact relationship between these cell types remains contentious but all share a type-2-inducing phenotype. MPP type 2 cells appear to differ from the other populations in that they have a myeloid, rather than lymphoid, origin.〔
Nuocytes have been shown to have a lymphoid origin and a developmental pathway that is dependent upon the transcription factor RORα and Notch signalling. Pro-T cell progenitors retain nuocyte developmental potential but, unlike T cells, the thymus is dispensable for their development.
== Notes and references ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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