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|Section2= |Section3= }} Nutlins are ''cis''-imidazoline analogs which inhibit the interaction between mdm2 and tumour suppressor p53, and which were discovered by screening a chemical library by Vassilev ''et al.'' Nutlin-1, Nutlin-2 and Nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly used in anti-cancer studies. Inhibiting the interaction between mdm2 and p53 stabilizes p53, and is thought to selectively induce a growth-inhibiting state called senescence in cancer cells. These compounds are therefore thought to work best on tumors that contain normal or "wild-type" p53. Nutlin-3 has been shown to affect the production of p53 within minutes. The more potent of the two enantiomers, (−)-Nutlin-3, can now be synthesized in a highly enantioselective fashion.〔Tyler A. Davis, Jeffrey N. Johnston. Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (−)-Nutlin-3, a potent p53/MDM2 inhibitor.''Chemical Science.'' The Royal Society of Chemistry. 2, February 2011. ()〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Nutlin」の詳細全文を読む スポンサード リンク
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