翻訳と辞書 Words near each other ・ Observer effect (information technology) ・ Observer effect (physics) ・ Observer Group ・ Observer officer ・ Observer Panel ・ Observer pattern ・ Observer Research Foundation ・ Observer status ・ Observer's Books ・ Observer's paradox ・ Observer-Dispatch ・ Observer-expectancy effect ・ Observer–Reporter ・ Observeur du Design ・ Observing Systems ・ Obscurin ・ Obscurior ・ Obscurior clarus ・ Obscurior davisi ・ Obscurior fragilis ・ Obscurior lateraprocessa ・ Obscurior niasiensis ・ Obscuris vera involvens ・ Obscurities (Stephin Merritt album) ・ Obscurity ・ Obscurity (band) ・ Obscurity (film) ・ Obscurodiscus ・ Obscuromyia ・ Obselidia Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Obscurin ： ウィキペディア英語版 Obscurin Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84033 )〕 Obscurin belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in the organization of myofibrils during sarcomere assembly. A mutation in the ''OBSCN'' gene has been associated with hypertrophic cardiomyopathy and altered obscurin protein properties have been associated with other muscle diseases. ==Structure== Human obscurin may exist as multiple splice variants of approximately 720 kDa, however the full-length nature of only one has been described to date. Obscurin is expressed in cardiac and skeletal muscle. The obscurin gene spans more than 150 kb, contains over 80 exons. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains.〔 The dominant location of obscurin in mature myofibrils is at the sarcomeric M-band.〔 Titin, obscurin, obscurin-like-1 and myomesin form a ternary complex at sarcomeric M-bands that is critical for sarcomere mechanics. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Obscurin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.