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Ochnaflavone : ウィキペディア英語版 | Ochnaflavone
Ochnaflavone, a secondary plant secondary metabolites, which belongs to the family of Biflavonoid, has been widely investigated in the past decades due to its unique ability to mediate biological activities, such as inhibition of phospholipase A2 and lymphocyte proliferation. It was first isolated from ''Ochna squarrosa'' Linn, a member of Ochnaceae family, in 1973. ==Synthesis==
The first total synthesis of ochnaflavone derivatives was achieved by Kawano group in 1973, followed by the Heerden group for the first time reporting the total synthesis the ochnaflavone by constructing a diaryl ether intermediate and assemble the two flavone nuclei through ring cyclization.〔Ndoile, M. M.; van Heerden, F. R., Total synthesis of ochnaflavone. Beilstein Journal of Organic Chemistry 2013, 9, 1346–1351.〕 To date, the field of biochemistry of biflavonoids is still wide open. Little is known about Ochnaflavone of its natural occurrence and biosythesis.〔Dey, P. M., METHODS IN PLANT BIOCHEMISTRY VOL 1 APL. Elsevier Science: 2012.〕
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