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Oleoyl-estrone
Oleoyl-estrone (OE) is a fatty acid ester of estrone. It is a naturally circulating hormone in animals, including humans. It was studied as a potential weight-loss drug, but failed to show benefit in clinical trials. It was first reported in 1996 to cause a body fat loss effect in rats in the ''International Journal of Obesity and Related Metabolic Disorders''. The animal research has all been conducted by the Nitrogen-Obesity Research Group of the University of Barcelona.
The compound was found to potently induce body-fat loss while preserving protein stores in animals which is the ultimate goal of an anti-obesity agent as body protein loss is an undesired but inevitable (to some degree) side effect of fat loss via calorie restriction.
==Mechanism of action ==
Oleoyl-estrone functions by reducing energy-intake without prescribed dietary restriction (forced dietary restriction in addition to OE actually led to protein losses) while maintaining energy expenditure (which normally falls as part of the adaptations to calorie restriction). The partitioning effects of this hormone leads to adipose stores being the source of energy that makes up for the energy deficit rather than protein stores.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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