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OmpT OmpT is an aspartyl protease found on the outer membrane of ''Escherichia coli''. OmpT is a subtype of the family of omptin proteases, which are found on some gram-negative species of bacteria. == Structure ==
OmpT is a 33.5 kDa outer membrane protein consisting of 10 antiparallel strands that are connected by 5 extracellular loops. The antiparallel strands form a beta barrel structure that spans the width of the membrane, creating a pore. OmpT can be coded from a gene on either a chromosome or on a plasmid in ''E. coli''. The sequences resulting from these two sources differ by 24-25% in the mature protease. Genetic differences between OmpT and other members of the omptin family are found in the extracellular loops, and therefore, this area is thought to be associated with substrate specificity.〔 Also, the barrel is relatively rigid, while the loops have more flexibility to bind to substrates of varying sizes.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「OmpT」の詳細全文を読む
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