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Valproate
Valproate (VPA), also known valproic acid, sodium valproate, and divalproex sodium, is a medication primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.〔(【引用サイトリンク】url=http://www.drugs.com/monograph/valproic-acid.html )〕 It is useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. It can be given intravenously or by mouth. Long acting formulations exist.〔
Common side effects include nausea, vomiting, sleepiness, and a dry mouth. Serious side effects can include liver problems and regular monitoring of liver function tests is therefore recommended. Other serious risks include pancreatitis and an increased suicide risk.〔 It is known to cause serious abnormalities in the baby if taken during pregnancy. Because of this it is not typically recommended in women of childbearing age. It is unclear how valproate works.〔
Valproate was first made in 1881 and come into medical use in 1962. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. In the United States it is available as a generic medication and costs about 0.60 USD per day. It is marketed under the brand names Depakote among others.〔
==Medical uses==
Its primary use to treatment epilepsy and bipolar disorder. It is also used to prevent migraine headaches.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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