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| Osteoimmunology ： ウィキペディア英語版 |
Osteoimmunology
Osteoimmunology (όστέον, ''osteon'' from Greek, “bone”; ''immunitas'' from Latin, “immunity”; and λόγος, ''logos'', from Greek “study”) is a field that emerged about 40 years ago that studies the interface between the skeletal system and the immune system, comprising the “osteo-immune system”. Osteoimmunology also studies the shared components and mechanisms between the two systems in vertebrates, including ligands, receptors, signaling molecules and transcription factors. Over the past decade, osteoimmunology has been investigated clinically for the treatment of bone metastases, rheumatoid arthritis (RA), osteoporosis, osteopetrosis, and periodontitis. Studies in osteoimmunology reveal relationships between molecular communication among blood cells and structural pathologies in the body.
==System similarities==
The RANKL-RANK-OPG (osteoprotegerin) axis is an example of an important signaling system functioning both in bone and immune cell communication. RANKL is expressed on osteoblasts and activated T cells, whereas RANK is expressed on osteoclasts, and dendritic cells (DCs), both of which can be derived from myeloid progenitor cells. Surface RANKL on osteoblasts as well as secreted RANKL provide necessary signals for osteoclast precursors to differentiate into osteoclasts. RANKL expression on activated T cells leads to DC activation through binding to RANK expressed on DCs. OPG, produced by DCs, is a soluble decoy receptor for RANKL that competitively inhibits RANKL binding to RANK.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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