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・ P. Amarasinghe
・ P. americana
・ P. americanus
・ P. amphibius
・ P. amplexicaulis
・ P. amseli
・ P. Ananda Kumar
・ P. Anandan
・ P-adic L-function
・ P-adic modular form
・ P-adic number
・ P-adic order
・ P-adic quantum mechanics
・ P-adic Teichmüller theory
・ P-adically closed field
P-ANCA
・ P-Anisic acid
・ P-Anisidine
・ P-Azobenzenearsonate
・ P-benzoquinone reductase (NADPH)
・ P-bodies
・ P-Bone Steak
・ P-box
・ P-CAD
・ P-chart
・ P-Chlorocresol
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・ P-class submarine
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P-ANCA : ウィキペディア英語版
P-ANCA

p-ANCA, or MPO-ANCA, or Perinuclear Anti-Neutrophil Cytoplasmic Antibodies, show a perinuclear staining pattern.
This pattern occurs because the vast majority of the antigens targeted by ANCAs are highly cationic (Positively charged) at pH 7.00. During ethanol (pH ~7.0 in water) fixation, antigens which are more cationic migrate and localize around the nucleus, attracted by its negatively charged DNA content. Antibody staining therefore results in fluorescence of the region around the nucleus.
==Targets==
By far the most common p-ANCA target is myeloperoxidase (MPO), a neutrophil granule protein whose primary role in normal metabolic processes is generation of oxygen radicals.
ANCA will less commonly form against alternative antigens that may also result in a p-ANCA pattern. These include lactoferrin; elastase; and cathepsin G.
When the condition is a vasculitis, the target is usually MPO. However, the proportion of p-ANCA sera with anti-MPO antibodies has been reported to be as low as 12%.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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