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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PARL ： ウィキペディア英語版 PARL Presenilins-associated rhomboid-like protein, mitochondrial also known as mitochondrial intramembrane cleaving protease PARL is an inner mitochondrial membrane protein that in humans is encoded by the ''PARL'' gene on chromosome 3.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55486 )〕 It is a member of the rhomboid family of intramembrane serine proteases.〔G. A. McQuibban, S. Saurya, M. Freeman, Nature 423, 537 (2003)〕 This protein is involved in signal transduction and apoptosis, as well as neurodegenerative diseases and type 2 diabetes.〔 ==Structure== Rhomboid family members share a conserved core of six transmembrane helices (TMHs), with the Ser and His residues required to form the catalytic dyad embedded in TMH-4 and TMH-6, respectively. This dyad is found deep below the membrane surface, which indicates that the hydrolysis of peptide bonds occurs within the hydrophobic phospholipid bilayer membrane. As a member of the Parl subfamily, PARL has an additional N-terminal TMH which may form a loop to the catalytic core. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PARL」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.