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PCSK6
Proprotein convertase subtilisin/kexin type 6 is an enzyme that in humans is encoded by the ''PCSK6'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5046 )〕 ''PCSK6'' is a protease that cleaves NODAL into an active form to help trigger the development of left/right (LR) asymmetry. It may also be involved in left and right handedness in humans.
== Function ==
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. Alternatively spliced transcript variants encoding different isoforms have been identified.〔
PCSK6 also cleaves and activates corin, a serine protease that regulates sodium homeostasis and blood pressure.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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