翻訳と辞書 Words near each other ・ Pen y Bryn ・ Pen y Brynfforchog ・ Pen y Castell ・ Pen y Clawdd Castle ・ Pen y Cymoedd ・ Pen y Fan ・ Pen y Gadair Fawr ・ Pen y Gaer ・ Pen y Garn ・ Pen yr Allt Uchaf ・ Pen yr Helgi Du ・ Pen yr Ole Wen ・ Pen's parade ・ Pen, India ・ Pen, Sword, Camisole ・ PEN-2 ・ Pen-allt ・ Pen-bont-rhyd-y-beddau ・ Pen-cae ・ Pen-dre ・ Pen-ek Karaket ・ Pen-Ek Ratanaruang ・ PEN-International ・ Pen-Link ・ Pen-llwyn ・ Pen-Llyn ・ Pen-Lôn ・ Pen-Mogi Nyeko ・ Pen-rhiw ・ Pen-Rhiw-Newydd Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PEN-2 ： ウィキペディア英語版 PEN-2 PEN-2 (presenilin enhancer 2) is a protein that is a regulatory component of the gamma secretase complex, a protease complex responsible for proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). The gamma secretase complex consists of PEN-2, APH-1, nicastrin, and the catalytic subunit presenilin.〔Kaether C, Haass C, Steiner H. (2006). Assembly, trafficking and function of gamma-secretase. ''Neurodegener Dis'' 3(4-5):275-83. PMID 17047368〕 PEN-2 is a 101-amino acid integral membrane protein likely with a topology such that both the N-terminus and the C-terminus face first the lumen of the endoplasmic reticulum and later the extracellular environment.〔Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. (2002). aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. ''Dev Cell'' 3(1):85-97. PMID 12110170 〕 Biochemical studies have shown that a conserved sequence motif D-Y-L-S-F at the C-terminus, as well as the overall length of the C-terminal tail, is required for the formation of an active gamma secretase complex.〔Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt S, Mathews P, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. (2004). Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes. ''J Biol Chem'' 279(45): 46455-46463〕 ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PEN-2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.