翻訳と辞書 Words near each other ・ PF Magic ・ PF Schio ・ PF Tek ・ PF Umbertide ・ PF-00446687 ・ PF-03550096 ・ PF-03654746 ・ PF-04457845 ・ PF-05089771 ・ PF-184563 ・ PF-219,061 ・ PF-2545920 ・ PF-3845 ・ PF-4455242 ・ PF-4800567 ・ PF-4840154 ・ PF-514273 ・ PF-592,379 ・ PF-89 ・ PF-9 ・ PF-98 ・ PF1 ・ PFA ・ PFA Fans' Favourites ・ PFA Fans' Player of the Year ・ PFA Footballer of the Year Awards ・ PFA Footcare Association (Canadian Chapter) ・ PFA Merit Award ・ PFA Players' Player of the Year ・ PFA Scotland Manager of the Year Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PF-4840154 ： ウィキペディア英語版 PF-4840154 |Section2= |Section3= }} PF-4840154 is pyrimidine derivative discovered by Pfizer at its Sandwich, Kent research center. The compound is a potent, selective activator of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel for in-vitro High-throughput screening purposes, and is superior to allyl isothiocyanate for this use. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PF-4840154」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.