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PNU-282,987
PNU-282,987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors. In animal studies, it shows nootropic effects, and derivatives may be useful in the treatment of schizophrenia,〔Redrobe, J. (2009). "Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice". ''European journal of pharmacology'' 602 (1): 58–65. PMID 18848931〕 although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget. == References ==
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