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PRG4
Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the ''PRG4'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10216 )〕 This proteoglycan acts as a joint/boundary lubricant.〔 == Function ==
Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature). The expression of lubricin has also been detected and the protein localized in tendon, meniscus,〔.〕 lung, liver, heart, bone, ligament, muscle, and skin.〔.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「PRG4」の詳細全文を読む
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