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P-selectin glycoprotein ligand-1
Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.
P-selectin glycoprotein ligand-1 is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.
==Posttranslational modification==
PSGL-1 protein requires two distinct posttranslational modifications to gain its selectin binding activity:
* sulfation of tyrosines
* the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans
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