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・ Psmith in the City
・ Psmith, Journalist
・ Psion Series 3
・ Psion Series 5
・ Psion Series 7
・ Psion Siena
・ Psion Teklogix
・ Psion Wavefinder
・ Psionex
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PSIP1
・ Psiphon
・ PSIPRED
・ Psique y sexo
・ PSIR Rembang
・ Psiram
・ Psirens
・ PSIS
・ PSIS Semarang
・ PSISra Sragen
・ Psithyrus
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・ Psittacanthus barlowii
・ Psittacanthus robustus


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PSIP1 : ウィキペディア英語版
PSIP1

PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the ''PSIP1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11168 )
== Function ==

PSIP1 has not been clearly linked to a specific cellular mechanism. The term LEDGF/p75 (Lens epithelium-derived growth factor) has entered common usage based on the initial characterization of PSIP1, however this is a misnomer, as the protein is present in most tissues and has no direct role in the development of lens epithelium. LEDGF/p75, a transcription coactivator, gained prominence as a host factor that assists HIV integration and is probably the only integrase interactor whose knock-down severely affects the HIV integration levels. The interaction between HIV integrase and human LEDGF/p75 is a promising target for anti-HIV drug discovery.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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