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・ Ptychadena gansi
・ Ptychadena grandisonae
・ Ptychadena guibei
・ Ptychadena harenna
・ Ptychadena ingeri
・ Ptychadena keilingi
・ Ptychadena longirostris
・ PTP (band)
・ PTP4A1
・ PTP4A2
・ PTP4A3
・ PTPd
・ PTPL College
・ PTPLAD1
・ PTPN1
PTPN11
・ PTPN12
・ PTPN13
・ PTPN14
・ PTPN18
・ PTPN2
・ PTPN21
・ PTPN22
・ PTPN23
・ PTPN3
・ PTPN4
・ PTPN5
・ PTPN6
・ PTPN7
・ PTPN9


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PTPN11 : ウィキペディア英語版
PTPN11

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the ''PTPN11'' gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
==Structure and function==
This phosphatase, along with its paralogue, Shp1, possesses a domain structure that consists of two tandem SH2 domains in its N-terminus followed by a protein tyrosine phosphatase (PTP) domain. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. Thus, Shp2 is auto-inhibited.
Upon binding to target phospho-tyrosyl residues, the N-terminal SH2 domain is released from the PTP domain, catalytically activating the enzyme by relieving this auto-inhibition.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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