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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PTPRU ： ウィキペディア英語版 PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10076 )〕 == Function == The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic tyrosine phosphatase domains, and thus represents a receptor-type PTP (RPTP). The extracellular region contains a meprin-A5 antigen-PTPmu (MAM) domain, one Ig-like domain and four fibronectin type III-like repeats, and thus is a member of the type R2B RPTP family. It was cloned by many groups and given different names, including PCP-2,〔 PTP pi, PTP lambda, hPTP-J, PTPRO,〔 and PTP psi. Other type R2B RPTPs include PTPRM, PTPRK, and PTPRT. Analysis of the genomic structure of PCP-2 suggests that it is the most distantly related of the type R2B RPTPS. RPTPs are able to remove phosphate moieties from tyrosine residues. Although the R2B family of RPTPs are characterized as having two tyrosine phosphatase domains in their intracellular domain, usually only one is catalytically active. A point mutation study suggests that only the first phosphatase domain of PCP-2 is catalytically active and able to dephosphorylate β-catenin. A recombinant protein with both PCP-2 phosphatase domains was also able to dephosphorylate EGFR.〔 However, when each of the two intracellular catalytic tyrosine phosphatase domains are expressed individually as recombinant proteins and assayed in vitro using the artificial substrate ρ-nitrophenol phosphate (pNPP), both the first and second intracellular tyrosine phosphatase domain were able to dephosphorylate pNPP.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PTPRU」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.