翻訳と辞書 Words near each other ・ PTT (Turkey) ・ PTT Bangkok Open ・ PTT Bulletin Board System ・ PTT Exploration and Production ・ PTT Global Chemical Public Company Limited ・ PTT ID ・ PTT İstanbul Cup ・ PTT Metro ・ PTT Public Company Limited ・ PTT Rayong F.C. ・ PTT Stadium ・ PTT Thailand Open ・ PTT Thailand Open (ATP) ・ PTTC ・ PTTC (Siem Reap, Cambodia) ・ PTTG1 ・ PTTG1IP ・ PTTK ・ PTTOW ・ PtTPS-LAS ・ PTU ・ PTU (film) ・ Ptuj ・ Ptuj Airport ・ Ptuj Castle ・ Ptuj City Stadium ・ Ptujska Cesta ・ Ptujska Gora ・ Pturek ・ Ptusza Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PTTG1 ： ウィキペディア英語版 PTTG1 Securin is a protein that in humans is encoded by the ''PTTG1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232 )〕 == Function == The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PTTG1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.