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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PUGNAc ： ウィキペディア英語版 PUGNAc PUGNA is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases. It was long thought that increased levels of ''O''-GlcNAc in human cells lead to Type II diabetes. O-GlcNAc levels were artificially raised with PUGNAc, which inhibits O-GlcNAcase, a beta-exo-N-acetylhexosaminidase which cleaves beta-O-linked-N-acetylglucosamine residues from glycoproteins. As a result of this inhibition, a type II diabetic phenotype was observed. Recent pharmacological studies using a more selective O-GlcNAcase inhibitor did not see this effect. However, genetic manipulation of O-GlcNAc levels is consistent with the effects observed by PUGNAc, namely insulin resistance upon elevation of O-GlcNAc levels. ==Fictional references== PUGNAc was used by Michael Scofield in the television series ''Prison Break'' to keep his blood sugar level high to appear diabetic and to be resistant to insulin shots he was receiving from the infirmary. He wanted this to get unlimited access to the infirmary building. Michael Scofield used PUGNAc to follow through with his escape plan. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PUGNAc」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.