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Panicudine
Panicudine (6-hydroxy-11-deoxy-13-dehydrohetisane) is a C20-diterpene alkaloid of the hetisine type, first isolated from ''Aconitum paniculatum''. It has empirical formula C20H25NO3 and a melting point of 249-250 °C. The structure was determined to be a hetisine type diterpene by noting infrared spectrum absorption bands of 3405 cm−1 (OH), 1718 (C=O), and 1650 (C=C), a proton magnetic resonance spectrum with "secondary hydroxy (4.02 ppm, m, 1H, W1/2 = 10 Hz), exomethylene (4.87 and 4.76 ppm, br.s, 1H each), and tertiary methyl (1.29 ppm, s, 3H) groups and the absence of ''N''-methyl, ''N''-ethyl, and methoxy groups." Additional ultraviolet spectrum and carbon-13 NMR data, confirmed by high resolution mass spectrometry, completed the determination of the structure. Panicudine was identified as an active antimicrobial substance in the chloroform extract of ''Polygonum aviculare'', a traditional herbal medicine of the Mediterranean coastal region. It has also been isolated from epigeal parts of ''Rumex pictus''. A variety of related alkaloids have been isolated from other natural sources. == References == 〔
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