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Pasteurellaceae
The Pasteurellaceae comprise a large family of Gram-negative bacteria. Most members live as commensals on mucosal surfaces of birds and mammals, especially in the upper respiratory tract.
Pasteurellaceae are typically rod-shaped, and are a notable group of facultative anaerobes. They can be distinguished from the related Enterobacteriaceae by the presence of oxidase, and from most other similar bacteria by the absence of flagella.
Bacteria in the family Pasteurellaceae have been classified into a number of genera based on metabolic properties, but these classifications are not generally accurate reflections of the evolutionary relationships between different species. ''H. influenzae'' was the first organism to have its genome sequenced and has been studied intensively by genetic and molecular methodologies.
==Molecular signatures==
Comparative analyses of Pasteurellaceae genomes have identified large numbers (>20) of conserved signature indels (CSIs) in different important proteins that are uniquely shared by all sequenced Pasteurellaceae species/strains, but are not found in any other bacteria. Based upon many other CSIs that are specific for subgroups of Pasteurellaceae species, it has been proposed to divide the family into at least two clades . One proposed clade includes ''Aggregatibacter'', ''Pasteurella'', ''Actinobacillus succinogenes'', ''Haemophilus influenzae'', ''Haemophilus somnus'', and ''Mannheimia succiniciproducens'', while the other includes ''Actinobacillus minor'', ''Actinobacillus pleuropneumoniae'', ''Haemophilus ducryi'', ''Haemophilus parasuis'', and ''Mannheimia haemolytica''.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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