翻訳と辞書
Words near each other
・ Patch-type granuloma annulare
・ Patcha Point
・ Patcha Ramachandra Rao
・ Patchacan
・ Patcham
・ Patcham Formation
・ Patcham High School
・ Patcham Place
・ Patcham Pylon
・ Patcham Tunnel
・ Patchanka
・ Patcharaporn Sittisad
・ Patcharee Deesamer
・ Patcharee Sangmuang
・ Patcharin Sooksai
Patched
・ Patched (malware)
・ Patched conic approximation
・ Patcheeswarar temple
・ Patchen
・ Patchen Markell
・ Patchen, California
・ Patches & Pockets
・ Patches (Chairmen of the Board song)
・ Patches from the Quilt
・ Patchett
・ Patchett House
・ Patchewollock
・ Patchi
・ Patchin Field


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Patched : ウィキペディア英語版
Patched

Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis that is important for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
== Discovery ==

The original mutations in the ptc gene were discovered in the fruit fly Drosophila melanogaster by 1995 Nobel Laureates Eric F. Wieschaus and Christiane Nusslein-Volhard and colleagues, and the gene was independently cloned in 1989 by Joan Hooper in the laboratory of Matthew P. Scott, and by Philip Ingham and colleagues.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Patched」の詳細全文を読む



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