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|Section2= |Section3= }} Pederin is a vesicant toxic amide with two tetrahydropyran rings, found in the haemolymph of the ''Paederus'' genus of beetles, including the Nairobi fly, belonging to the Staphylinidae family. It was first characterized by processing 25 million field-collected ''P. fuscipes''.〔(Bugs Don’t Have to Bite to Do Damage:The Tale of the Paederus Beetle )〕 It makes up approximately 0.025% of an insects weight (for ''P. fuscipes'').〔 It has been demonstrated that the production of pederin relies on the activities of an endosymbiont (''Pseudomonas ssp.'') within ''Paederus''. The manufacture of pederin is largely confined to adult female beetles—larvae and males only store pederin acquired maternally (i.e., through eggs) or by ingestion.〔 ==Mode of action== Pederin blocks mitosis at levels as low as 1 ng/ml, by inhibiting protein and DNA synthesis without affecting RNA synthesis, prevents cell division, and has been shown to extend the life of mice bearing a variety of tumors. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pederin」の詳細全文を読む スポンサード リンク
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