翻訳と辞書 Words near each other ・ Pegah Anvarian ・ Pegah Emambakhsh ・ Pegah F.C. ・ Pegah Golpayegan ・ Pegah Karaj F.C. ・ Pegah Khozestan F.C. ・ Pegah Tehran F.C. ・ Pegaito a la Pared ・ Pegalajar ・ Pegando con tubo ・ Pegangsaan, Menteng ・ Peganum ・ Peganum harmala ・ Peganum nigellastrum ・ Pegao ・ Pegaptanib ・ Pegar ou Largar ・ Pegaret Anthony ・ Pegas ・ PEGASE ・ Pegasid ・ Pegasidae ・ Pegasides ・ Pegasids ・ Pegaso ・ Pegaso BMR ・ Pegaso Troner ・ Pegaso Z-102 ・ Pegaso Z-207 ・ Pegaso Z-403 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Pegaptanib ： ウィキペディア英語版 Pegaptanib Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age-related macular degeneration (AMD). It was discovered by NeXstar Pharmaceuticals and licensed in 2000 to EyeTech Pharmaceuticals, now OSI Pharmaceuticals, for late stage development and marketing in the United States. Outside the US pegaptanib is marketed by Pfizer. Approval was granted by the ] (FDA) in December 2004. ==Mechanism of action== Pegaptanib is a pegylated anti-vascular endothelial growth factor (VEGF) aptamer, a single strand of nucleic acid that binds with specificity to a particular target. Pegaptanib specifically binds to the 165 isoform of VEGF, a protein that plays a critical role in angiogenesis (the formation of new blood vessels) and increased permeability (leakage from blood vessels), two of the primary pathological processes responsible for the vision loss associated with neovascular AMD. Pegaptanib works as an antagonist to VEGF, which when injected into the eye blocks the actions of VEGF. This then reduces the growth of the blood vessels located within the eye and works to control the leakage and swelling.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pegaptanib」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.