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・ Pegu Range
・ Pegu, Iran
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Pegvisomant
・ Pegwell Bay
・ Pegwell Bay, Kent – a Recollection of October 5th 1858
・ Pegwn Mawr
・ Pegwood
・ Pegylated interferon
・ PEGylation
・ Pegz
・ Peg’s Cantina
・ Peh
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・ Pehchaan (1993 film)
・ Pehchaan (DD1 TV series)


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Pegvisomant : ウィキペディア英語版
Pegvisomant

Pegvisomant (trade name Somavert) is a growth hormone receptor antagonist used in the treatment of acromegaly. It is used if the tumor of the pituitary gland causing the acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful. It is delivered as a powder that is mixed with water and injected under the skin.〔
==Structure==
Pegvisomant is a protein containing 191 amino acid residues to which several polyethylene glycol polymers have been covalently bound in order to slow clearance from the blood. The protein is a modified version of human growth hormone designed to bind to and block the growth hormone receptor. It is manufactured using genetically modified ''E. coli'' bacteria. The polyethylene glycol polymers are subsequently added chemically.〔(【引用サイトリンク】title=Scientific Discussion of Somavert )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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